Sample research paper on diabetes.

sample research paper on diabetes

The emergence of new drugs for IBS-D has been slow and there is a need for new treatments, including drug-free treatments, which are easy to use and suitable for different patient groups. Currently available drug-free treatments include Enterosgel®, an intestinal adsorbent approved for use in IBS-D and acute diarrhoea and available over-the-counter in the UK and 30 countries worldwide.

  • Diabetes kezelési szabványok 2
  • The role of swimming in preserving health | Slovak Journal of Sport Science
  • Bean kötőelemek cukorbetegség kezelése

The aim of this randomised, double-blind, placebo-controlled, multi-centre study is to test the efficacy and safety of Enterosgel® compared to placebo in symptomatic treatment in IBS-D.

Participants meeting the required abdominal pain and stool consistency criteria over a 2-week screening period will be randomly allocated to receive blinded treatment Enterosgel® or placebo for 8 weeks.

sample research paper on diabetes cukormentes ételek recept

This will be followed by an 8-week open-label treatment phase with Enterosgel®. Participants will be allowed to adjust their daily dosage during both phases based on their symptoms.

Besides studies revealing the molecular mechanisms underlying the associations of telomere defects and mitochondrial functions, investigations of mitochondrial DNA copy number mtDNAcn and telomere length TL in healthy and disease phenotypes have likewise begun, with the aim of gaining more insights about their relationship in humans.

Participants will then return to standard care and those who responded to treatment will receive a follow-up call 8 weeks later. Co-medication with loperamide will be permitted and use recorded.

sample research paper on diabetes ingadozó vércukorszint tünetei

The primary outcome measure is the percentage of participants defined as responders for abdominal pain and stool consistency during at least 4 weeks in the 8-week blinded phase.

Secondary outcome measures include stool frequency, stool consistency, abdominal pain, bloating, urgency, adequate relief, questionnaire scores and rescue medication use. Exploratory outcomes will be assessed in subsets of participants including qualitative and quantitative data on faecal microorganisms and biomarkers and gut-related measurements from magnetic resonance imaging data. A study design with blinded phase followed by an open-label phase was chosen to encourage participation and study completion.

Demonstrating that Enterosgel® is effective and safe in IBS-D could encourage adoption by patients and pathophysiology of diabetic nephropathy professionals and foster future clinical trials assessing its use in related conditions.

sample research paper on diabetes inulin cukorbetegség kezelésében

Prospectively registered on 14 November The specific cause of the disorder is not fully understood [ 45 ], but among other factors may sample research paper on diabetes genetic disposition, gut immune dysfunction, immune activation, gut dysbiosis, infective and dietary triggers and changes to gut permeability [ 6 — 8 ].

IBS is common worldwide, with an estimated prevalence globally of It occurs in all age groups, including children and the elderly, although it predominantly affects adults of working age.

The prevalence of each subtype can vary depending on the classification used. Overall healthcare costs for IBS are comparable to those of other chronic diseases with a similar prevalence, such as congestive heart failure, hypertension, asthma and migraine [ 16 ].

IBS is a challenging condition to treat mainly as a result of its complex multi-factorial nature. Currently, no single universally effective approach is available for the management of IBS [ 13 ], but lifestyle or dietary changes are often implemented as the first step of management.

sample research paper on diabetes a jelentősége a téma a cukorbetegség kezelésében

Probiotic use is also becoming more common and has shown to improve symptoms in patients with IBS-D [ 17 ]. Potential treatment targets include mediators sample research paper on diabetes as histamine and serotonin, which are postulated to play a causative role in IBS, and bacterial products and bile acids, which also have been implicated in the generation of IBS symptoms [ 78 ].

Recommended Articles A cukorbetegséghez társuló idegrendszeri károsodás kialakulásának mechanizmusa ma sem teljes mértékben tisztázott, bár az utóbbi évtizedben számos, részben terápiás konzekvenciával járó adat vált ismertté. Az endoneuralis véráramlás csökkenése részben a primer haemostasis károsodásának, a koagulációs rendszer trombogén irányú elmozdulásának következménye. A hyperglykaemia a szuperoxid-anion fokozott képződése révén a glikolízisben kulcsszerepet játszó glicerin-aldehidfoszfát-dehidrogenáz aktivitásának csökkenéséhez, alternatív anyagcsereutak poliol- hexóz-amin- diacil-glicerol- proteinkináz-C anyagcsereút, fehérjeglikáció aktiválódásához vezet. A végglikációs fehérjék fokozzák a nukleáris faktor κ-B aktivitását, vazoaktív tényezők és citokinek interleukin-1, -6, tumornekrózis-faktor-α termelődését. A patogenetikai alapon nyugvó oki kezelés célja a neuropathiás károsodás progressziójának lassítása, megállítása vagy visszafordítása.

Medications for treating IBS-related symptoms include antispasmodics, psychotropic agents, bulking agents and 5-HT receptor antagonists. However, many of these drugs have proven to be inadequate for the relief of symptoms and some have safety issues [ 18 ]. There is, therefore, a need for well-designed clinical trials on new therapies for IBS-D.

sample research paper on diabetes cukorbetegség jövője

Previous clinical studies on intestinal adsorbents have shown some improvement in the symptoms of IBS-D, but are likely to have been underpowered for many important outcome measures [ 2324 ]. The rationale for the use of intestinal adsorbents in the management of IBS symptoms is their ability to bind to various mediators and toxins and remove them from the gastrointestinal tract in the stools.

Diabetes Research

There is also evidence from research on the intestinal adsorbent dioctahedral smectite for enhancement of the intestinal barrier function, which counteracts disruption from pro-inflammatory cytokines [ 2526 ].

One of the intestinal adsorbents approved for use in IBS-D and available over-the-counter in the UK is Enterosgel®, which is a drug-free treatment developed for binding toxins and other harmful substances in the gastrointestinal tract [ 27 ].

The role of swimming in preserving health

It is suitable for different patient groups, including children and the elderly. Although there has been extensive research on Enterosgel®, including two pilot studies in IBS-D reporting a normalisation of stool frequency and form and decrease in bodily pain [ 2829 ], and a UK based study in acute diarrhoea [ 30 ], so far none of the conducted studies have included a placebo control arm. The difficulty has been that gel-like substances with a consistency similar to commercially available Enterosgel® for example gelatin or starch based could potentially have effects in the gastrointestinal tract and their suitability for use as a placebo sample research paper on diabetes require validation.

Tizenhét évesen a Gyöngyös otthonában már keretben is volt, három hónappal később pedig két gólt ért el a Tatabánya elleni bronzmérkőzésen. Pár hónapja újabb nagy lépcsőfokhoz ért a pályafutása, hiszen az idei szezonban nyújtott kimagasló teljesítménye miatt bemutatkozhatott a felnőtt válogatottban is, ahol aztán olyan meggyőző formát mutatott, hogy az egyiptomi világbajnokságon is szerepelhetett, de egyébiránt azóta is tagja a felnőtt válogatott szűk keretének. Ezzel egyidőben több nemzetközi klubcsapat érdeklődését is felkeltette, amelyeket első ízben visszautasított, de a világ legerősebb bajnokságában szereplő Stuttgart meggyőző invitálásának — klubunk vezetésével folyamatosan egyeztetve — már nem mondott nemet, így a nyártól óriási kihívás elé néz. Klubunk döntése értelmében a Csurgói Kézilabda Klub hivatalos mérkőzésein a 7-es számú mezt kizárólag csapatkapitányunk viselheti a jövőben, így távozásával ezt a mezszámot ideiglenesen visszavonultatjuk, hiszen, ha úgy adódik, akkor klubunk tárt karokkal várja vissza saját nevelésű kézilabdázónkat.

This randomised, double-blind, placebo-controlled, multi-centre study will use an innovative approach to overcome this challenge. The aim is to test the efficacy and safety of Enterosgel® over placebo in symptomatic treatment in adults with IBS-D diagnosed according to the Rome IV criteria.

  1. Tervezhet velünk!

The study involves a 2-week screening phase, after which eligible participants are randomised to blinded treatment Enterosgel® or placebo for 8 weeks. Following the double-blind treatment phase, all participants will receive open-label Enterosgel® treatment for a further 8 weeks.

  • A kezelés a nemi szervek diabetes mellitusban
  • Pál Pánczél - ODT Personal data sheet
  • Cukorborsó vendéglő étlap

At the end of the open-label treatment phase, all participants will return to standard care; however, those who responded to open-label treatment will receive a follow-up call 8 weeks later.

Olvassa el is